Headache
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Randomized Controlled Trial Multicenter Study Clinical Trial
Montelukast for migraine prophylaxis: a randomized, double-blind, placebo-controlled study.
To evaluate the efficacy and tolerability of montelukast 20 mg in the prophylactic treatment of migraine. ⋯ Montelukast 20 mg was well tolerated in migraine patients but was not an effective prophylactic for prevention of migraine.
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Comparative Study
The medical costs of migraine and comorbid anxiety and depression.
To examine the direct medical costs associated with migraine, when diagnosed alone and in conjunction with anxiety and/or depression in adults and children. ⋯ This analysis quantifies the economic impact of a migraine diagnosis for both adults and children. The results of this analysis demonstrate that individuals identified as migraineurs have significantly higher medical costs than healthy comparators, with or without comorbid anxiety and/or depression. This study also suggests that clinicians should be aware that while proper treatment of migraine with effective acute and prophylactic therapy is important, attention must also be directed to comorbid conditions.
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To investigate clinical, MRI, and radioisotope findings and therapeutic outcome of the syndrome of spontaneous intracranial hypotension (SIH). ⋯ Patients with SIH have distinct MRI and sometimes radioisotope cisternographic abnormalities and generally respond favorably to conservative management.
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To study the clinical features of nummular headache (NH) and get an approach to its epidemiology. ⋯ NH emerges as a clear-cut clinical picture. It is a noninfrequent primary headache. The particular topography suggests the pain has a probable epicranial source conveyed by, or originated in, one/a few terminal branch(es) of the cutaneous nerves of the scalp.