The Journal of experimental medicine
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1. A technique for determining the respiratory response to carbon dioxide on the Peabody principle is described. 2. ⋯ The respiratory response to carbon dioxide as expressed by the total pulmonary ventilation is slightly greater at high oxygen percentages (90 per cent +/-) than at normal oxygen percentages in the inspired air. 4. Respiratory fatigue may consist of two elements-one nervous, manifesting itself in increased excitability of the center and a more marked response when the demand for pulmonary ventilation is small, the other muscular and involving an inability to respond when the demand for pulmonary ventilation is great.