Jornal de pediatria
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Jornal de pediatria · Sep 2014
TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis.
To analyze toll-like receptor (TLR)-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. ⋯ This study investigated the innate immune response in septic newborns. Septic newborns that relied almost exclusively on the innate immune system showed little in vivo response at monocyte activation, suggesting impaired immune response and increased susceptibility to infection.
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Jornal de pediatria · Sep 2014
[Application of the Pediatric Index of Mortality 2 in pediatric patients with complex chronic conditions].
To evaluate the performance of the Pediatric Index of Mortality 2 (PIM2) in a pediatric intensive care unit (PICU) with a high prevalence of patients with complex chronic conditions (CCCs), and compare the performance between patients with and without CCCs. ⋯ PIM2 showed poor performance in patients with CCCs and in the general population. This result may be secondary to differences in the characteristics between the study samples (high prevalence of patients with CCCs); the performance of the PIM2 should not be ruled out.