Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Clinical TrialClozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up.
To compare the efficacy and safety of clozapine in drug induced psychosis in Parkinson's disease (PD). ⋯ Clozapine at a mean dose lower than 50 mg/day improves drug induced psychosis in PD without significant worsening of motor function, and the effect wears off once the treatment stops.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Isolated middle cerebral artery disease: clinical and neuroradiological features depending on the pathogenesis.
Isolated atherosclerotic middle cerebral artery (MCA) disease is often difficult to differentiate from cardioembolic disease if intracranial atherosclerosis coexists with cardiac disease. ⋯ Clinical and neuroradiological characteristics can differentiate isolated atherosclerotic MCA disease from MCA disease associated with potential sources of cardiac embolism, and may reflect the differences in underlying pathogenesis.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Letter Case ReportsAcute head drop after cervical hyperflexion injury.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
ReviewSize of the treatment effect on cognition of cholinesterase inhibition in Alzheimer's disease.
Six cholinesterase inhibitors (ChEIs) have been tested in people with Alzheimer's disease, using methods currently required for regulatory approval. The clinical importance of their treatment effects is controversial. ⋯ ChEIs produce small-moderate effect sizes in clinical trials which are reproducible and demonstrate a dose response. Better descriptions of the patterns of treatment response are needed to guide individual patient decisions about the effectiveness of treatment, but group effects are evident and appear large enough to be clinically detectable.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Case ReportsReversible bilateral internuclear ophthalmoplegia associated with FK506.
A 50 year old man developed tonic-clonic seizures while receiving cyclosporin A after orthotopic cardiac transplant. The seizures resolved after cessation of cyclosporin A. ⋯ A temporal association was found between his symptoms and the serum FK506 concentrations. Withdrawal of the intravenous FK506 led to prompt resolution of the bilateral internuclear ophthalmoplegia.