Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Randomized Controlled Trial Comparative Study Clinical TrialRandomised control trial of tongue acupuncture versus sham acupuncture in improving functional outcome in cerebral palsy.
Traditional Chinese medicine (TCM) has been used historically in the treatment of cerebral palsy (CP). We investigated the efficacy of acupuncture in improving the motor function of children with CP. ⋯ An improvement in motor function of CP subjects is seen following a short course of acupuncture.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Real time PCR quantification of frataxin mRNA in the peripheral blood leucocytes of Friedreich ataxia patients and carriers.
The most common causative mutation of Friedreich ataxia (FRDA) is the unstable hyperexpansion of an intronic GAA triplet repeat that impairs frataxin transcription. Using real time quantitative PCR, we showed that FRDA patients had residual levels of frataxin mRNA ranging between 13% and 30% and that FRDA carriers had about 40% of that of controls. ⋯ We found an inverse correlation between the number of GAA repeats and frataxin mRNA levels. Real-time quantitative PCR may represent an alternative assay for FRDA molecular diagnosis.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Non-convulsive status epilepticus: a profile of patients diagnosed within a tertiary referral centre.
Non-convulsive status epilepticus (NCSE) is an under-recognised but treatable condition with considerable associated morbidity. The files of adult admissions were reviewed over four years, during which time 50 episodes of NCSE were diagnosed in 45 patients. These findings suggest a broad age range with various states of mental acuity and an association with both learning disabilities and acute systemic infection. Approximately half of the patients had a previous diagnosis of epilepsy at the time of admission, and half had a history of generalised tonic-clonic seizures immediately before the onset of their illness.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Meta AnalysisTau gene and Parkinson's disease: a case-control study and meta-analysis.
To investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson's disease and to report a meta-analysis on all previously published data ⋯ Homozygosity for the tau H1 is associated with an increased risk of Parkinson's disease. This adds to the growing body of evidence that common genetic variation contributes to the pathogenesis of this disorder.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2004
Clinical TrialThe effect of immunomodulatory treatment on multiple sclerosis fatigue.
To assess the effects of glatiramer acetate and beta interferon on fatigue in multiple sclerosis. ⋯ The odds of reduced multiple sclerosis fatigue were around twice as great with glatiramer acetate treatment as with beta interferon. Confirmation of this result is required.