Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Sep 2004
Clinical TrialSexual well being in parkinsonian patients after deep brain stimulation of the subthalamic nucleus.
To evaluate changes in sexual well being in a group of patients with Parkinson's disease following deep brain stimulation (DBS) of the subthalamic nucleus (STN). ⋯ DBS of STN appears to affect sexual functioning in a small but positive way. Male patients with Parkinson's disease, especially when under 60, appeared more satisfied with their sexual well being over a short term follow up period.
-
J. Neurol. Neurosurg. Psychiatr. · Sep 2004
Clinical TrialSubthalamic nucleus stimulation in advanced Parkinson's disease: blinded assessments at one year follow up.
To measure the effect of deep brain stimulation (DBS) of the subthalamic nucleus in patients with advanced Parkinson's disease. ⋯ The 30% improvement in UPDRS motor scores was a more modest result than previously reported. DBS did not improve functional capacity independent of drug use. Its chief benefits were reduction in wearing off duration and dyskinesia severity.
-
J. Neurol. Neurosurg. Psychiatr. · Sep 2004
Oculomotor abnormalities parallel cerebellar histopathology in autism.
To investigate cerebellar function in autism by measuring visually guided saccades. ⋯ The observed saccadic abnormalities suggest a functional disturbance in the cerebellar vermis or its output through the fastigial nuclei, consistent with reported cerebellar histopathology in autism. The pattern of mild hypometria and variable saccade accuracy is consistent with chronic rather than acute effects of cerebellar vermis lesions reported in clinical and non-human primate studies, as might be expected in a neurodevelopmental disorder. The different patterns of oculomotor deficits in individuals with autism with and without delayed language development suggest that pathophysiology at the level of the cerebellum may differ depending on an individual's history of language development.