Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Editorial CommentNeuromyelitis optica and anti-aquaporin-4 antibodies: widening the clinical phenotype.
Presence of anti‐aquaporin‐4 antibodies in patients with neuromyelitis optica has wide implications
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Comparative StudyCord atrophy separates early primary progressive and relapsing remitting multiple sclerosis.
The onset of multiple sclerosis is relapsing remitting or primary progressive. An improved understanding of the causes of early progressive disability in primary progressive multiple sclerosis (PPMS) could provide mechanistic targets for therapeutic intervention. ⋯ Grey matter and white matter of the brain are abnormal in both early RRMS and PPMS, but cord atrophy is present only in PPMS. This is concordant with myelopathy being the usual clinical presentation of PPMS. Measurement of cord atrophy seems to be clinically relevant in PPMS treatment trials.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Clinical TrialMultimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study.
Evoked potentials are used in the functional assessment of sensory and motor pathways. Their usefulness in monitoring the evolution of multiple sclerosis has not been fully clarified. ⋯ These results suggest that evoked potential is a good marker of the severity of nervous damage in multiple sclerosis and may have a predictive value regarding the evolution of disability.
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Headache or neck pain is a frequent symptom of spontaneous cervical artery dissection (sCAD). ⋯ Pain may be the only symptom in sCAD, even when multiple arteries are dissected. Pain topography, dynamics, quality and intensity were heterogeneous. Data from this study lend support to recommendations favouring imaging studies of the cervical arteries in patients with new-onset unexplained headache or neck pain.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Case ReportsChronic spinal cord stimulation in medically intractable orthostatic tremor.
Orthostatic tremor with its sense of unsteadiness when standing may have a devastating effect on affected persons. Currently, there are no other treatment options in those who do not respond or who do not tolerate medical treatment. ⋯ The results of this pilot study indicate that SCS may be an option in patients with otherwise intractable orthostatic tremor.