Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Aug 2012
Increased risk of multiple sclerosis relapse after in vitro fertilisation.
Exogenous sexual steroids together with pregnancy have been shown to influence the risk of relapses in multiple sclerosis (MS). Treatments used during assisted reproductive techniques may consequently influence the short term evolution of MS by modifying the hormonal status of the patient. The objective of this study was to determine if there was an increased risk of developing exacerbations in women with MS after in vitro fertilisation (IVF). ⋯ An increased relapse rate was observed in this study after IVF in patients with MS and may be partly related both to IVF failure and the use of GnRH agonists.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2012
Randomized Controlled TrialClonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba.
To assess the effect of Ginkgo biloba and clonazepam, a γ-aminobutyric acid (GABA)-receptor agonist, upon tinnitus. ⋯ Clonazepam is effective in treating tinnitus; G biloba is ineffective.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2012
White and grey matter abnormalities in patients with SPG11 mutations.
Mutations in SPG11 are the most frequent known cause of autosomal recessive hereditary spastic paraplegia. Corpus callosum thinning is a hallmark of the condition but little is known about damage to other structures in the CNS. ⋯ Widespread white matter damage in patients with SPG11 mutations has been demonstrated. Grey matter atrophy was prominent in both the thalamus and basal ganglia but not in the cerebral cortex. These findings suggest that neuronal damage/dysfunction is more widespread than previously recognised in this condition.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2012
Cortical border-zone infarcts: clinical features, causes and outcome.
To report the clinical features, causes and outcome of cerebral cortical border-zone infarcts BZI (C-BZI). ⋯ Some clinical features are overrepresented in such infarctions, including initial transient symptoms preceding the onset of a completed deficit, transcortical aphasia and early seizures. Despite lower initial severity, C-BZIs justify early management in stroke unit, often followed by carotid surgery, leading to an overall good prognosis.