Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2016
Review Meta AnalysisSafety and diagnostic value of brain biopsy in HIV patients: a case series and meta-analysis of 1209 patients.
Early brain biopsy may be indicated in HIV patients with focal brain lesion. This study aimed to evaluate and compare the safety and diagnostic value of brain biopsy in HIV patients in the pre-highly active antiretroviral therapy (HAART) versus post-HAART era via meta-analysis. Appropriate studies were identified per search criteria. ⋯ The median survival for HIV patients who underwent biopsy in the post-HAART era was 225 days (90-2446). Brain biopsy in HIV patients is safe with high diagnostic yield. Early brain biopsy should be considered in patients without classic presentation of toxoplasmosis encephalitis.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2016
Multicenter Study Comparative StudyDoes age affect surgical outcomes in patients with degenerative cervical myelopathy? Results from the prospective multicenter AOSpine International study on 479 patients.
In general, older patients with degenerative cervical myelopathy (DCM) are felt to have lower recovery potential following surgery due to increased degenerative pathology, comorbidities, reduced physiological reserves and age-related changes to the spinal cord. This study aims to determine whether age truly is an independent predictor of surgical outcome and to provide evidence to guide practice and decision-making. ⋯ Older age is an independent predictor of functional status in patients with DCM. However, patients over 65 with DCM still achieve functionally significant improvement after surgical decompression.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2016
Review Meta Analysis Comparative StudyAntipsychotic medications for the treatment of delirium: a systematic review and meta-analysis of randomised controlled trials.
We performed an updated meta-analysis of antipsychotic treatment in patients with delirium, based on a previous meta-analysis published in 2007. ⋯ Our results suggested that SGAs have a benefit for the treatment of delirium with regard to efficacy and safety compared with haloperidol. However, further study using larger samples is required.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2016
Review Meta AnalysisConstipation preceding Parkinson's disease: a systematic review and meta-analysis.
To systematically review published literature to estimate the magnitude of association between premorbid constipation and later diagnosis of Parkinson's disease. ⋯ This systematic review and meta-analysis demonstrates that people with constipation are at a higher risk of developing Parkinson's disease compared with those without and that constipation can predate Parkinson's diagnosis by over a decade.