Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2017
Randomized Controlled TrialPhase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease.
Evidence for longer term exercise delivery for people with Parkinson's disease (PwP) is deficient. ⋯ PwP exercised safely and the possible long-term benefits observed support a substantive evaluation of this community programme.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2017
Randomized Controlled TrialCognitive outcome after ventral capsule/ventral striatum stimulation for treatment-resistant major depression.
We report the neuropsychological outcome of 25 patients with treatment-resistant major depressive disorder (TRD) who participated in an Institutional Review Board (IRB)-approved randomised double-blind trial comparing active to sham deep brain stimulation (DBS) in the anterior limb of the ventral capsule/ventral striatum (VC/VS). ⋯ These data suggest that VC/VS DBS in patients with TRD does not significantly affect neuropsychological function. Age at surgery, regardless of stimulation status, may be related to cognitive outcome at the individual patient level.