Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2021
Early atypical signs and insula hypometabolism predict survival in multiple system atrophy.
We aim to search for predictors of survival among clinical and brain 18F-FDG positron emission tomography (PET) metabolic features in our cohort of patients with multiple system atrophy (MSA). ⋯ The clinical prognosis factors we have described support published studies. Here, we also suggest that brain PET is of interest for prognosis assessment and in particular in the search for left insula hypometabolism. Moreover, SSRIs are a potential drug candidate to slow the progression of the disease.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2021
Longitudinal observational study investigating outcome measures for clinical trials in inclusion body myositis.
To describe decline in muscle strength and physical function in patients with sporadic inclusion body myositis (IBM). ⋯ This prospective observational study represents the largest IBM cohort to date. Measures of patient progress evaluated in this study accurately predict disease progression in a reliable and useful way to be used in trial design.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2021
Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease.
The clinical phenotype of the rare behavioural variant of Alzheimer's disease (bvAD) is insufficiently understood. Given the strong clinico-anatomical correlations of tau pathology in AD, we investigated the distribution of tau deposits in bvAD, in-vivo and ex-vivo, using positron emission tomography (PET) and postmortem examination. ⋯ Both in-vivo and ex-vivo, patients with bvAD showed heterogeneous distributions of tau pathology. Since key regions involved in behavioural regulation were not consistently disproportionally affected by tau pathology, other factors are more likely driving the clinical phenotype in bvAD.