Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2023
Distinct disease mechanisms may underlie cognitive decline related to hearing loss in different age groups.
Hearing loss in older adults is associated with increased dementia risk. Underlying mechanisms that connect hearing loss with dementia remain largely unclear. ⋯ Hearing loss was associated with amyloid binding in younger-old individuals only, and with cognitive decline in both age groups. These results suggest that mechanisms linking hearing loss with risk for dementia depends on age.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2023
Contemporary study of multiple sclerosis disability in South East Wales.
A contemporary understanding of disability evolution in multiple sclerosis (MS) is an essential tool for individual disease management and planning of interventional studies. We have used prospectively collected longitudinal data to analyse disability progression and variation in a British MS cohort. ⋯ These data provide a detailed contemporary model of disability outcomes in a representative population-based MS cohort. They support a trend of increasing time to disability milestones compared with historical reference populations, and document disability variation with the use of transitional matrices. In addition, they provide essential information for patient counselling, clinical trial design, service planning and offer a comparative baseline for assessment of therapeutic interventions.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2023
Time to steroids impacts visual outcome of optic neuritis in MOGAD.
To characterise the response to treatment of inaugural optic neuritis (ON) in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). ⋯ Time to MP affects functional but also structural visual outcomes of ON in MOGAD.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2023
SARS-CoV-2 omicron breakthrough infections in patients with multiple sclerosis.
It is unclear which patients with multiple sclerosis (MS) are most susceptible for omicron breakthrough infections. ⋯ SARS-COV-2 omicron breakthrough infections are more prevalent in patients with MS on anti-CD20 therapies and S1PR modulators compared with other patients with MS, which correlated with decreased humoral responses after vaccination. Humoral responses after infection were higher in S1PR modulator-treated patients in comparison to patients on anti-CD20 therapies, suggesting that immunological protection from contracting infection or repeated exposures may differ between these therapies.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2023
Observational StudyAssociation between early treatment of multiple sclerosis and patient-reported outcomes: a nationwide observational cohort study.
Timing of disease-modifying therapy affects clinical disability in multiple sclerosis, but it is not known whether patient reported outcomes are also affected. This study investigates the relationship between treatment timing and patient-reported symptoms and health-related quality of life. ⋯ Earlier commencement of disease-modifying treatment was associated with better patient-reported physical symptoms when measured using a disease-specific metric; however, general quality of life was not affected. This indicates that other factors may inform patients' overall quality of life.