Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Sep 2024
Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease.
Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere. ⋯ Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2024
Directional deep brain stimulation electrodes in Parkinson's disease: meta-analysis and systematic review of the literature.
Since their introduction in 2015, directional leads have practically replaced conventional leads for deep brain stimulation (DBS) in Parkinson's disease (PD). Yet, the benefits of directional DBS (dDBS) over omnidirectional DBS (oDBS) remain unclear. This meta-analysis and systematic review compares the literature on dDBS and oDBS for PD. ⋯ CRD42023438056.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2024
Multicenter StudyRedefining migraine prevention: early treatment with anti-CGRP monoclonal antibodies enhances response in the real world.
Anti-CGRP monoclonal antibodies (anti-CGRP MAbs) are approved and available treatments for migraine prevention. Patients do not respond alike and many countries have reimbursement policies, which hinder treatments to those who might respond. This study aimed to investigate clinical factors associated with good and excellent response to anti-CGRP MAbs at 6 months. ⋯ This is the largest real-world study of migraine patients treated with anti-CGRP MAbs. It provides evidence that higher migraine frequency and greater disability at baseline reduce the likelihood of responding to anti-CGRP MAbs, informing physicians and policy-makers on the need for an earlier treatment in order to offer the best chance of treatment success.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2024
Increased apathy post-interstitial laser capsulotomy for refractory obsessive-compulsive disorder.
MRI guided laser interstitial thermal therapy (M-LITT) capsulotomy has proven to be efficacious in decreasing refractory obsessive-compulsive disorder (OCD) related symptomatology yet capsulotomy either via radiosurgery or radiofrequency ablation has in some patients led to increased apathy following surgery. The current case series aims to investigate objective patient-reported change in apathy, disinhibition, depression, and executive dysfunction following anterior capsulotomy via M-LITT for OCD. ⋯ Most patients in the current cohort achieved full-or-partial OCD recovery. Yet, 60% of patients also reported significant increases in apathy, despite experiencing a decrease in depression symptoms, with stable disinhibition and executive dysfunction. Despite these promising improvements in OCD symptomatology following M-LITT, further investigations of the impact of surgery and lesion location on apathy levels is clearly warranted using objective, quantifiable methods.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2024
Meta AnalysisResective epilepsy surgery and its impact on depression in adults: a systematic review, meta-analysis, and implications for future research.
How epilepsy surgery influences the bidirectional relationship of epilepsy and depression remains poorly defined. ⋯ CRD42022355386.