Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2016
Neuronal autoantibodies in mesial temporal lobe epilepsy with hippocampal sclerosis.
Our aim was to investigate the prevalence of neuronal autoantibodies (NAbs) in a large consecutive series with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to elucidate the clinical and laboratory clues for detection of NAbs in this prototype of frequent, drug-resistant epilepsy syndrome. ⋯ This first systematic screening study of various NAbs showed 22.5% seropositivity belonging mostly to VGKC-complex antibodies in a large consecutive series of patients with MTLE-HS. Our results indicated a VGKC-complex autoimmunity-related subgroup in the syndrome of MTLE-HS.