Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Oct 2006
Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis.
Whether the association between mild hyperhomocysteinaemia and ischaemic stroke is the consequence of a predisposing genetic background or is due to the confounding influence of established predisposing factors remains to be determined. ⋯ A consistency of phenotype-disease analysis and genotype-disease analysis is indicated by analysing specific subcategories of patients, defined by the distribution of established risk factors. The assumption that the Hcy-stroke relationship is unlikely due to a reverse-causality bias is indirectly supported by our data.
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J. Neurol. Neurosurg. Psychiatr. · Oct 2006
Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease.
To investigate the effects of attentional deficits on activities of daily living (ADL) in patients with dementia associated with Parkinson's disease (PDD). ⋯ Impaired attention is an important determinant of ADL functions in patients with PDD.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Editorial CommentNeuromyelitis optica and anti-aquaporin-4 antibodies: widening the clinical phenotype.
Presence of anti‐aquaporin‐4 antibodies in patients with neuromyelitis optica has wide implications
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Comparative StudyCord atrophy separates early primary progressive and relapsing remitting multiple sclerosis.
The onset of multiple sclerosis is relapsing remitting or primary progressive. An improved understanding of the causes of early progressive disability in primary progressive multiple sclerosis (PPMS) could provide mechanistic targets for therapeutic intervention. ⋯ Grey matter and white matter of the brain are abnormal in both early RRMS and PPMS, but cord atrophy is present only in PPMS. This is concordant with myelopathy being the usual clinical presentation of PPMS. Measurement of cord atrophy seems to be clinically relevant in PPMS treatment trials.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2006
Clinical TrialMultimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study.
Evoked potentials are used in the functional assessment of sensory and motor pathways. Their usefulness in monitoring the evolution of multiple sclerosis has not been fully clarified. ⋯ These results suggest that evoked potential is a good marker of the severity of nervous damage in multiple sclerosis and may have a predictive value regarding the evolution of disability.