Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Oct 2004
Randomized Controlled Trial Clinical TrialEfficacy of deep brain stimulation of the subthalamic nucleus in Parkinson's disease 4 years after surgery: double blind and open label evaluation.
To evaluate the long term (4 years) efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in advanced Parkinson's disease. ⋯ DBS of the STN provides a significant and persistent anti-parkinsonian effect in advanced Parkinson's disease 4 years after surgery.
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J. Neurol. Neurosurg. Psychiatr. · Oct 2004
Multicenter StudySpinal cord infarction: clinical and magnetic resonance imaging findings and short term outcome.
Most studies on spinal cord infarction have been conducted in single centres; they usually consisted of case reports, or of larger series of patients recruited over a large period of time, with heterogeneous diagnostic procedures. Therefore, the clinical and radiological presentation of spinal cord infarcts and their short term outcome remain poorly understood. ⋯ The two month outcome mainly depends on the initial severity of the neurological deficit; however, a few patients with a severe impairment at onset had a good outcome, especially when proprioception remained normal at onset. The study does not support the hypothesis that pain occurs more frequently in small spinal infarcts.
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J. Neurol. Neurosurg. Psychiatr. · Oct 2004
Axonal sensorimotor neuropathy in patients with beta-thalassaemia.
The purpose of this study was to investigate the prevalence of peripheral neuropathy in patients with beta-thalassaemia. ⋯ This study showed a high prevalence of a predominantly sensory neuropathy in patients with beta-thalassaemia. The electrophysiological data suggest that the underlying pathology is an axonopathy. Chronic hypoxia of the nerves resulting from severe anaemia may contribute to the pathogenesis of this neuropathy.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2004
Clinical TrialSexual well being in parkinsonian patients after deep brain stimulation of the subthalamic nucleus.
To evaluate changes in sexual well being in a group of patients with Parkinson's disease following deep brain stimulation (DBS) of the subthalamic nucleus (STN). ⋯ DBS of STN appears to affect sexual functioning in a small but positive way. Male patients with Parkinson's disease, especially when under 60, appeared more satisfied with their sexual well being over a short term follow up period.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2004
Clinical TrialSubthalamic nucleus stimulation in advanced Parkinson's disease: blinded assessments at one year follow up.
To measure the effect of deep brain stimulation (DBS) of the subthalamic nucleus in patients with advanced Parkinson's disease. ⋯ The 30% improvement in UPDRS motor scores was a more modest result than previously reported. DBS did not improve functional capacity independent of drug use. Its chief benefits were reduction in wearing off duration and dyskinesia severity.