Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Electromagnetic function of polymicrogyric cortex in congenital bilateral perisylvian syndrome.
Congenital bilateral perisylvian syndrome (CBPS) is characterised by bilateral perisylvian polymicrogyria and suprabulbar paresis. Mild tetraparesis, cognitive impairment, and epilepsy are frequently associated. Sensory deficits are surprisingly rare, even though polymicrogyria often extends to auditory and sensorimotor cortex. ⋯ Plastic changes of sensory and motor cortex location suggest disturbed cortex organisation in CBPS patients. Because the polymicrogyric cortex of CBPS patients may embed normal functions in unexpected locations, functional mapping should be considered before brain surgery.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Outcomes following childhood head injury: a population study.
To identify outcomes following head injury (HI) among a population of children admitted to one hospital centre and to compare outcomes between different severity groups. ⋯ Children admitted with mild HI may be at risk of poor outcomes, but often do not receive routine hospital follow up. A postal questionnaire combined with the KOSCHI to assess outcomes after HI may be used to identify children who would benefit from clinical assessment. Further research is needed to identify factors that place children with mild HI at risk of late morbidity.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Craniocervical dystonia questionnaire (CDQ-24): development and validation of a disease-specific quality of life instrument.
To develop and test a questionnaire for measuring quality of life in patients with craniocervical dystonia. ⋯ The CDQ-24 is the first fully validated and disease specific questionnaire to evaluate quality of life of patients with cervical dystonia and blepharospasm and we propose its use in clinical trials as well as in daily clinical practice.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Clinical TrialClozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up.
To compare the efficacy and safety of clozapine in drug induced psychosis in Parkinson's disease (PD). ⋯ Clozapine at a mean dose lower than 50 mg/day improves drug induced psychosis in PD without significant worsening of motor function, and the effect wears off once the treatment stops.