Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Feb 2023
MOG antibody-associated encephalitis in adult: clinical phenotypes and outcomes.
We investigated the clinical characteristics and outcomes of myelin oligodendrocyte glycoprotein (MOG) antibody-associated autoimmune encephalitis (MOGAE) in adult patients. ⋯ Outcomes are different according to the three phenotypes in MOGAE. Short immunotherapy maintenance is associated with relapse, and brain atrophy was associated with poor outcomes. Patients with dual antibodies of NMDAR and MOG have a high relapse rate.
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J. Neurol. Neurosurg. Psychiatr. · Feb 2023
Impairments to executive function in emerging adults with Huntington disease.
The clinical diagnosis of Huntington disease (HD) is typically made once motor symptoms and chorea are evident. Recent reports highlight the onset of cognitive and psychiatric symptoms before motor manifestations. These findings support further investigations of cognitive function across the lifespan of HD sufferers. ⋯ This work provides strong evidence that impairments in executive function occur as early as the second decade of life, well before anticipated motor onset. Future investigations should delineate whether these impairments in executive function are due to abnormalities in neurodevelopment or early sequelae of a neurodegenerative process.
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J. Neurol. Neurosurg. Psychiatr. · Feb 2023
Reliable virtual clinical assessment in spino-bulbar muscular atrophy (SBMA).
Spino-bulbar muscular atrophy (SBMA), caused by a CAG repeat expansion in the androgen receptor gene, affects adult men and results in muscle atrophy and weakness in the bulbar and limb muscles and signs of partial androgen insensitivity. During the COVID-19 pandemic, outpatients' visits have been reduced to preserve safety of frail patients, and telehealth was largely employed. ⋯ Our data show that telehealth is a valid tool to monitor patients with SBMA: AMAT and SBMA-FRS scales can be effectively, reliably and easily administered remotely.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2023
Letter Randomized Controlled Trial Controlled Clinical TrialImpact of tDCS on persistent COVID-19 olfactory dysfunction: a double-blind sham-controlled study.