Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Clinical TrialSpinal cord MRI in clinically isolated optic neuritis.
One hundred and fifteen patients with clinically isolated optic neuritis underwent magnetic resonance imaging (MRI) of the brain and spinal cord within 3 months of the onset of symptoms. ⋯ Using existing criteria, spinal cord imaging rarely contributes to the diagnosis in patients with clinically isolated optic neuritis.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Prevalence and impact of depression and pain in neurology outpatients.
We examined the prevalence and health related quality of life (HRQoL) of depression and/or pain in neurology outpatients. ⋯ Depression and pain are common in newly referred neurology outpatients and have substantial negative effects on patients' physical and mental health. Pain is more likely than depression to be recognised and treated by neurologists.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Case ReportsAwakenings from persistent vegetative state: report of three cases with parkinsonism and brain stem lesions on MRI.
Three patients with a persistent vegetative state after severe head injury are reported. They recovered from a prolonged disturbance of consciousness after the administration of levodopa. ⋯ On magnetic resonance imaging, the distribution of lesions implied a diffuse axonal injury involving the substantia nigra or ventral tegmental area. The existence of patients whose dopaminergic systems may have been selectively damaged by a severe head injury should be recognised because such individuals may respond to levodopa treatment.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Case ReportsFamilial motor neurone disease with dementia: phenotypic variation and cerebellar pathology.
To characterise the neuropathological phenotypes of two affected individuals from a family with an unusual clinical phenotype resembling motor neurone disease and dementia. ⋯ The clinical and neuropathological findings in this family are best described as an example of familial motor neurone disease with dementia. Intraneuronal ubiquitin inclusions together with agyrophilic, neurofilament positive torpedoes were present within the cerebellar cortex, both previously unrecognised findings in this group of diseases.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Case ReportsA variant of multifocal motor neuropathy with acute, generalised presentation and persistent conduction blocks.
Multifocal motor neuropathy with persistent conduction blocks is classically described as a chronic neuropathy with progressive onset, and acute forms have not previously been characterised. We report four cases of severe motor impairment with acute and generalised onset and with persistent motor conduction blocks. ⋯ Because of the persistence of multifocal motor conduction blocks for several weeks or months as the isolated electrophysiological feature, these cases could not be consistent with Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy. They suggest an original variant of multifocal motor neuropathy with an acute and generalised initial presentation and persistent motor conduction blocks affecting all four limbs.