European journal of clinical investigation
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Eur. J. Clin. Invest. · May 2012
Urinary liver-type fatty acid-binding protein level as a predictive biomarker of contrast-induced acute kidney injury.
Contrast-induced acute kidney injury (CI-AKI) is a well-known complication of contrast medium exposure in patients with chronic kidney disease. However, there are no biological markers to accurately predict the onset of CI-AKI. Liver-type fatty acid-binding protein (L-FABP), an intracellular carrier protein for free fatty acids, is markedly upregulated and abundantly expressed in the proximal tubules after renal ischaemia. We prospectively investigated whether urinary L-FABP is a suitable marker for the prediction of CI-AKI. ⋯ Urinary L-FABP level is useful for predicting the onset of CI-AKI before contrast medium exposure.
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Eur. J. Clin. Invest. · May 2012
An integrative view on the carotid artery alterations in metabolic syndrome.
Metabolic syndrome (MetS) is a multiple risk factor paradigm widely considered in risk management. We aimed to investigate carotid artery alterations in MetS and the underlying risk factors. ⋯ Carotid alterations consequent upon MetS ultimately developed subclinical and clinical atherosclerosis, the underlying risk factors for which were abdominal obesity, hypertension, ageing and low level of HDL-C.