European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2016
Lung function, inflammation and cardiovascular mortality in Africans.
The link between impaired lung function and cardiovascular outcome is well established in European and American populations. It is possible that this association may be driven by a systemic spillover of inflammation occurring within the lungs. As several studies have found an increased level of inflammatory markers in African populations, we aimed to establish the contribution of lung function in predicting all-cause and cardiovascular mortality in Africans, whilst taking inflammatory markers into account. ⋯ FVC, but not FEV1 , is a strong predictor of both all-cause and CV mortality in black South Africans, which may be mediated by inflammation.
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Eur. J. Clin. Invest. · Nov 2016
ReviewPrimary focal segmental glomerulosclerosis: miRNAs and targeted therapies.
Primary focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome. ⋯ The aim of this review was to summarize reports showing a direct relation between miRNAs and primary FSGS. In addition, the impact of identified miRNAs on treatment response, prediction of the disease onset as well as the regulation in different disease activities is summarized.