European journal of clinical investigation
-
Eur. J. Clin. Invest. · Feb 2016
Clinical implications of nonsarcomeric gene polymorphisms in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is characterized by cardiomyocyte hypertrophy and fibrosis. Although is an autosomal dominant trait, a group of nonsarcomeric genes have been postulated as modifiers of the phenotypic heterogeneity. ⋯ Our study suggests that COL1A1 polymorphism (2046G>T) is an independent predictor of prognosis in HCM patients supporting the importance of nonsarcomeric genes on clinical prognosis in HCM.
-
Eur. J. Clin. Invest. · Feb 2016
The TyG index may predict the development of cardiovascular events.
Cardiovascular disease (CVD) is the worldwide leading cause of morbidity and mortality. An early risk detection of apparently healthy people before CVD onset has clinical relevance in the prevention of cardiovascular events. We evaluated the association between the product of fasting plasma glucose and triglycerides (TyG index) and CVD. ⋯ The TyG index, a simple measure reflecting insulin resistance, might be useful to early identify individuals at a high risk of developing a cardiovascular event.
-
Eur. J. Clin. Invest. · Feb 2016
A long-term risk-benefit analysis of low-dose aspirin in primary prevention.
The long-term risk-benefit effect of occasional and regular use of low-dose aspirin (≤ 100 mg per day) in primary prevention of vascular diseases and cancers was calculated. ⋯ A long-term regular use of low-dose aspirin might not be better than occasional use in the primary prevention against major vascular diseases and cancer.