European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 2017
Randomized Controlled TrialAcetylsalicylic acid in critically ill patients: a cross-sectional and a randomized trial.
Despite decades of clinical use, the pharmacokinetics and the effects of acetylsalicylic acid (ASA) in critically ill patients remain ill-defined. We aimed to investigate the pharmacokinetics and the effects of different ASA formulations during critical illness. ⋯ There is a very high prevalence of HTPR in critically ill patients on peroral ASA therapy, caused by an incomplete suppression of TXB2 and/or by impaired absorption of ASA.
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Eur. J. Clin. Invest. · Jul 2017
Randomized Controlled TrialSerum phosphate is related to adiposity in healthy adults.
Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations. ⋯ Serum phosphate is inversely associated with measures of adiposity in both women and men, largely independently of PTH. FGF23 might mediate these associations. This relationship may be an unrecognized confounder in some of the correlates of serum phosphate already described.