European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2020
Observational StudyHemodynamics of an Iatrogenic Atrial Septal Defect (IASD) after MitraClip Implantation.
The MitraClip procedure requires transseptal access of the left atrium with a 24F guiding sheath. We evaluated invasively whether a MitraClip induced iatrogenic atrial septal defect (IASD) leads to development of a relevant interatrial shunt and right ventricular overload. ⋯ Our data show that the MitraClip procedure does not induce a relevant interatrial shunt or right ventricular overload. In fact, future studies will have to show whether the IASD may even be beneficial in selected patient populations by left atrial volume and pressure relief.
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Eur. J. Clin. Invest. · Oct 2020
The role of resistin and myeloperoxidase in severe sepsis and septic shock: results from the ALBIOS trial.
Inflammatory biomarkers are useful in detecting patients with sepsis. The prognostic role of resistin and myeloperoxidase (MPO) has been investigated in sepsis. ⋯ High levels of MPO, but not of resistin, on day 1 were able to predict 90-day mortality. These findings may either suggest that early hyper-activation of neutrophils is detrimental in patients with sepsis or reflect the burden of the inflammatory process caused by sepsis. Further studies are warranted to deepen these aspects (ALBIOS ClinicalTrials.gov Identifier: NCT00707122).
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Eur. J. Clin. Invest. · Oct 2020
A Mendelian Randomization Analysis: The Causal Association Between Serum Uric Acid and Atrial Fibrillation.
Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis using genetic instrumental variables (IVs). ⋯ The serum UA level was independently associated with the AF risk.