European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2020
The role of resistin and myeloperoxidase in severe sepsis and septic shock: results from the ALBIOS trial.
Inflammatory biomarkers are useful in detecting patients with sepsis. The prognostic role of resistin and myeloperoxidase (MPO) has been investigated in sepsis. ⋯ High levels of MPO, but not of resistin, on day 1 were able to predict 90-day mortality. These findings may either suggest that early hyper-activation of neutrophils is detrimental in patients with sepsis or reflect the burden of the inflammatory process caused by sepsis. Further studies are warranted to deepen these aspects (ALBIOS ClinicalTrials.gov Identifier: NCT00707122).
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Eur. J. Clin. Invest. · Oct 2020
Prevalence and control of hypertension among patients on hemodialysis.
Earlier studies provided considerably variable estimates on the prevalence and control rates of hypertension in haemodialysis because of their heterogeneity in definitions and blood pressure (BP) measurement techniques applied to detect hypertension. ⋯ This study shows that the prevalence, but mainly the control rates of hypertension in patients on haemodialysis, differs between peridialytic and interdialytic BP recordings. Therefore, the wider use of home BP monitoring may improve the determination of BP control status in this high-risk population.
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Eur. J. Clin. Invest. · Oct 2020
A Mendelian Randomization Analysis: The Causal Association Between Serum Uric Acid and Atrial Fibrillation.
Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis using genetic instrumental variables (IVs). ⋯ The serum UA level was independently associated with the AF risk.
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Eur. J. Clin. Invest. · Oct 2020
Sociodemographic factors, current asthma and lung function in an urban child population.
We aimed to assess which sociodemographic factors are associated with current asthma and indicators of lung function in 10-year-old children. ⋯ Among 10-year-old children, ethnic background was associated with current asthma and lung function after adjusting for a wide range of sociodemographic factors. No associations were found between socioeconomic status indicators and current asthma. Explanations for these associations such as language barriers, suboptimal care or pathophysiological differences require further investigation.