European journal of clinical investigation
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Eur. J. Clin. Invest. · Dec 2020
Observational StudyAccuracy of prehospital point-of-care lactate in early in-hospital mortality.
Emergency medical services (EMS) routinely face complex scenarios where decisions should be taken with limited clinical information. The development of fast, reliable and easy to perform warning biomarkers could help in such decision-making processes. The present study aims at characterizing the validity of point-of-care lactate (pLA) during prehospital tasks for predicting in-hospital mortality within two days after the EMS assistance. ⋯ Our results highlight the clinical importance of prehospital pLA to determine the in-hospital risk of mortality. The incorporation of pLA into the EMS protocols could improve the early identification of risky patients, leading to a better care of such patients.
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Eur. J. Clin. Invest. · Dec 2020
Review Meta AnalysisEffects of Exercise Programs on Pain, Disease Activity and Function in Ankylosing Spondylitis: A Meta-Analysis of Randomzied Controlled Trials.
To evaluate the effects of exercise programmes on pain, function and disease activity in patients with ankylosing spondylitis (AS). ⋯ For patients with AS, exercise programmes improve pain, function and disease activity. To confirm the results, more well-designed randomized controlled trials with large number of patients are required.
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Eur. J. Clin. Invest. · Dec 2020
LetterDisclosing Conflict of Interest Does Not Mitigate Healthcare Bias and Harm: It is Time to Sever Industry Ties.
Disclosing conflict of interest is widely believed to mitigate bias and harm from industry entanglement in healthcare research, education and practice. However, evidence is lacking of disclosure-related mitigation. Radical and extensive severing of industry ties to health care is necessary to curtail industry-related bias and harm.
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Eur. J. Clin. Invest. · Dec 2020
Cardiovascular risk estimation with 5 different algorithms before and after 5 years of bDMARD treatment in Rheumatoid Arthritis.
Assessing cardiovascular (CV) risk represents a challenge for clinicians because more variables can impact CV risk. The aim of this study was to evaluate the change of CV risk after 5 years of biological treatment in rheumatoid arthritis (RA) patients and impact of prolonged low disease activity on 5 different CV risk algorithms. ⋯ Algorithms commonly used to estimate 10-year CV risk in RA perform differently. Scores that include specific inflammatory RA-related variables seem to decrease with amelioration of disease activity. Further investigations are warranted to explore the predictive value of their changing over time.
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Studies reported that soluble B7-H4 (sB7-H4) was significantly related to the progression and prognosis of inflammatory diseases, and whether sB7-H4 is related to the severity and prognosis of acute pancreatitis (AP) timely has not been reported. ⋯ Soluble B7-H4 could be used as a marker for the diagnosis, severity assessment and poor prognosis assessment of AP patients, which may have potential clinical applications.