European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2020
Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease.
Kawasaki disease (KD) is an acute, self-limited vasculitis. Coronary artery aneurysm (CAA) serves as a major contributor to the long-term prognosis of KD. In addition, acute KD usually also leads to several kinds of noncoronary cardiac abnormalities (NCA) involving the pericardium, myocardium and endocardium. ⋯ Noncoronary cardiac abnormalities is almost universal in acute KD and mainly manifests as valvular regurgitation. However, it has no influence on clinical classification and the response to IVIG therapy.
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Eur. J. Clin. Invest. · Apr 2020
Time-dependent incidence and risk for myocardial infarction in patients with alcoholic cirrhosis.
It remains unsettled whether alcoholic cirrhosis is a risk factor for myocardial infarction (MI). ⋯ The incidence rate of MI was increased the first year following a diagnosis of alcoholic cirrhosis, in particular in women and those with most severe liver disease. Due to the competing risk of non-MI mortality, the MI-risk was not increased.
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Eur. J. Clin. Invest. · Apr 2020
Completeness of reporting of case reports in high-impact medical journals.
Case reports represent a relevant, timely and important study design in advancing medical scientific knowledge. They allow integration between clinical practice and clinical epidemiology. We aimed to assess the completeness of reporting (COR) of case reports published in high-impact journals. We assessed the COR of case reports using the CARE guidelines. ⋯ Overall completeness of case reports in included journals is high especially for CARE endorsing and dedicated journals but reporting of some items could be improved. Ongoing and future evaluations of endorsement status of reporting guidelines in medical journals should be assessed to improve completeness and reduce waste of clinical research, including case reports.
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Eur. J. Clin. Invest. · Apr 2020
Systemic redox imbalance in patients with nonalcoholic fatty liver disease.
Oxidative stress is one of the major pathologic mechanisms for the progression of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the relationship between the extent of steatosis and oxidative stress parameters in patients with NAFLD. ⋯ Increased extent of hepatic steatosis could be considered as a pathological mechanism for enhancing oxidative stress in patients with NAFLD, independent of obesity, and is exacerbated further in patients with more severe condition.