European journal of clinical investigation
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Eur. J. Clin. Invest. · Feb 2021
Review Meta AnalysisInhaled corticosteroids and risk of lung cancer: A systematic review and meta-analysis.
Current studies investigating the association between inhaled corticosteroid (ICS) use and risk of lung cancer have yielded inconsistent findings. The aim of this systematic review and meta-analysis was to pool all currently available data to estimate this association. ⋯ The present study suggested that ICS use was associated with decreased risk of lung cancer. However, our findings should be interpreted with caution because most original studies were judged to be at high risk of immortal time bias.
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Eur. J. Clin. Invest. · Feb 2021
Meta AnalysisEffects of antidiabetic drugs on psoriasis: A meta-analysis.
Psoriasis, a chronic inflammatory skin disease, poses an elevated risk of developing diabetes mellitus. ⋯ The current evidence demonstrates therapeutic efficacy of pioglitazone, which may be a treatment option in patients with psoriasis and diabetes mellitus.
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Eur. J. Clin. Invest. · Feb 2021
Review Meta AnalysisMicroRNA-223 in Gastrointestinal Cancers: A Systematic Review and Diagnostic Meta-Analysis.
Several studies have been conducted on the diagnostic role of miR-223 in cancers related to the digestive system. However, the diagnostic role of this microRNA in gastrointestinal (GI) cancers has not been fully elucidated. This meta-analysis aimed to accurately assess the diagnostic role of circulating miR-223 in GI cancers. ⋯ Our meta-analysis showed the value of circulating miR-223 levels in the early diagnosis of diverse digestive system carcinomas.
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Eur. J. Clin. Invest. · Feb 2021
Review Meta AnalysisA meta-analysis on the diagnostic performance of magnetic resonance imaging and transient elastography in Nonalcoholic Fatty Liver Disease.
Noninvasive methods have been used for the assessment of hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD). The aim was to assess the efficacy and accuracy of both magnetic resonance imaging(MRI) and transient elastography(TE) for the evaluation of hepatic steatosis. ⋯ MRI-PDFF and TE-CAP both provide highly accurate noninvasive approaches for quantifying and staging hepatic steatosis in NAFLD. Compared with TE-CAP, MRI-PDFF is significantly more accurate for evaluating dichotomized grades of steatosis.
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Eur. J. Clin. Invest. · Feb 2021
ReviewIncidence and treatment of arrhythmias secondary to coronavirus infection in humans: a systematic review.
The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide resulting in significant morbidity and mortality. Arrhythmias are prevalent and reportedly, the second most common complication. Several mechanistic pathways are proposed to explain the pro-arrhythmic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A number of treatment approaches have been trialled, each with its inherent unique challenges. This rapid systematic review aimed to examine the current incidence and available treatment of arrhythmias in COVID-19, as well as barriers to implementation. ⋯ Patients with SARS-CoV-2 are at an increased risk of arrhythmias. Drug therapy is pro-arrhythmogenic and may result in TdP and SCD in these patients. Risk assessment and regular QTc monitoring are imperative for safety during the treatment course. Further studies are needed to guide future decision-making.