European journal of clinical investigation
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Eur. J. Clin. Invest. · Feb 2021
Salivary antioxidant enzymes associated with oral toxicity in haematopoietic cell transplantation: An observational study.
In haematopoietic cell transplantation (HCT), oral mucositis and xerostomia are related to conditioning-related oxidative stress. The role of salivary antioxidant enzymes in oral toxicity is poorly described. The aim of this study was to verify the association between salivary antioxidant enzymes and oral mucositis and xerostomia in HCT. ⋯ Salivary antioxidant enzymes changed before and during early periods after HCT. The increase in salivary superoxide dismutase suggested partial activation of the salivary antioxidant system and was associated with xerostomia.