European journal of clinical investigation
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Eur. J. Clin. Invest. · Mar 2021
Physical activity may not be associated with long-term risk of dementia and Alzheimer's disease.
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer's disease (AD). ⋯ In middle-aged Caucasian men, various physical activity exposures were not associated with all-cause dementia or AD. Future studies should address biases due to reverse causation and regression dilution and should involve objective measures of physical activity.
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Eur. J. Clin. Invest. · Mar 2021
Artificial neural network-based prediction of prolonged length of stay and need for post-acute care in acute coronary syndrome patients undergoing percutaneous coronary intervention.
Prolonged length of stay (LOS) and post-acute care after percutaneous coronary intervention (PCI) is common and costly. Risk models for predicting prolonged LOS and post-acute care have limited accuracy. Our goal was to develop and validate models using artificial neural networks (ANN) to predict prolonged LOS > 7days and need for post-acute care after PCI. ⋯ Our ANN-based models accurately predicted LOS and need for post-acute care. Larger studies for replicability and longitudinal studies for evidence of impact are needed to establish these models in current PCI practice.
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Eur. J. Clin. Invest. · Mar 2021
Review Meta AnalysisPlatelet-to-lymphocyte ratio and prognosis in STEMI: a meta-analysis.
Platelet-to-lymphocyte ratio (PLR) is a haematological index which reflects increased level of inflammation and thrombosis. We aimed to summarize the potential prognostic role of PLR for the in-hospital and long-term outcomes in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI) in a meta-analysis. ⋯ Higher PLR predicts poor in-hospital and long-term prognosis in STEMI patients after pPCI.
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Eur. J. Clin. Invest. · Mar 2021
Review Meta AnalysisDirect oral anticoagulants and advanced liver disease: a systematic review and meta-analysis.
Direct oral anticoagulants (DOACs) are recommended for stroke prevention in patients with atrial fibrillation (AF) or for treatment of deep vein thrombosis, although some concerns about safety and efficacy were raised on the use of these drugs in patients with advanced liver disease (ALD). We want to investigate the association of DOACs use with the bleeding and ischaemic risk. ⋯ DOACs are associated with a lower incidence of bleeding and may be an attractive therapeutic option in patients with cirrhosis.
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Eur. J. Clin. Invest. · Mar 2021
Review Meta AnalysisPrognostic value of cystatin C in patients with acute coronary syndrome:A Systematic Review and Meta-analysis.
Circulating cystatin C has been considered as an independent predictor of cardiovascular and all-cause mortality in the general population. The purpose of this study was to evaluate the prognostic value of baseline circulating cystatin C levels in patients with acute coronary syndrome (ACS) through meta-analysis. ⋯ Our meta-analysis showed that high cystatin C levels were significantly associated with the death risk and MACE in ACS patients. Therefore, cystatin C can be included in the risk stratification model to guide the treatment of high-risk ACS patients.