European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 2021
Creatine kinase and bleeding in patients with acute coronary syndromes.
The association between elevated creatine kinase (CK) and bleeding in patients with acute coronary syndrome (ACS) remains incompletely investigated. We undertook this study to assess whether there is an association between elevated CK activity and the risk for bleeding in contemporary patients with ACS. ⋯ In patients with ACS, peak CK activity was independently associated with increased 30-day incidence of bleeding.
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Eur. J. Clin. Invest. · Jul 2021
Multiplying effects of COVID-19 lockdown on metabolic risk and fatty liver.
Social containment measures imposed in Europe during the lockdown to face COVID-19 pandemic can generate long-term potential threats for metabolic health. ⋯ Strict measures of social containment-even short-term-pave the way to the increased risk of metabolic abnormalities in the medium-long term. In this context, adherence to Mediterranean diet and regular physical activity play a protective role both in terms of weight gain and fatty liver development/progression, with implication for primary and secondary prevention. When adopting measures imposing social containment, intensive educational campaigns must increase public awareness about beneficial effects of healthy lifestyles.
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Eur. J. Clin. Invest. · Jul 2021
Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells.
Ferroptosis is an iron-dependent and oxidative cell death form. Recent studies suggested that circular RNAs (circRNAs) regulated ferroptosis in tumour cells. Circ_0007142 was identified as a carcinogenic molecule in colorectal cancer (CRC), but its function on ferroptosis in CRC remains unknown. ⋯ All these findings proved that circ_0007142/miR-874-3p/GDPD5 axis regulated tumorigenesis and ferroptosis of CRC cells. Circ_0007142 might be an available marker for ferroptosis in CRC therapy.