European journal of clinical investigation
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Eur. J. Clin. Invest. · Dec 2022
Review Meta AnalysisIncidence of immune checkpoint inhibitor mediated cardiovascular toxicity: A systematic review and meta-analysis.
Immune checkpoint inhibitors (ICI) are a novel class of anti-cancer therapy becoming increasingly associated with fatal cardiovascular toxicities (CVTs). The aim is to determine the incidence of CVTs in cohorts treated with ICIs as sole anti-cancer therapy. ⋯ ICI-mediated CVTs are rare and potentially fatal. The role of CV risk factors in their development remains unclear.
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Eur. J. Clin. Invest. · Dec 2022
Multicenter StudyEffect of PCSK9 inhibitors on cholesterol remnants and lipid residual risk: the LIPID-REAL Registry.
Monoclonal antibodies that inhibit the proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce low-density lipoprotein cholesterol (LDLc) by 55%, regardless of baseline treatments. Nonetheless, the effect of other lipid parameters, such as cholesterol remnants or, the so-called lipid residual risk, is unknown. ⋯ This multicenter and retrospective registry of real-world patients treated with PCSK9 inhibitors demonstrates a positive effect on cholesterol remnants and lipid residual risk beyond LDLc reductions.
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Eur. J. Clin. Invest. · Dec 2022
Meta AnalysisPrognostic value of soluble urokinase-type plasminogen activator receptor in coronary artery disease: A meta-analysis.
A potential inflammatory biomarker, soluble urokinase-type plasminogen activator receptor (suPAR) has been utilized to assist the prognostic assessment of coronary artery disease (CAD) patients; however, outcomes have been inconsistent. The prognostic relevance of suPAR as a predictor of CAD patient adverse outcomes was therefore examined. ⋯ In patients with coronary disease, suPAR may have prognostic value for both all-cause and cardiovascular mortality but not for other major cardiovascular events.
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Eur. J. Clin. Invest. · Dec 2022
Meta AnalysisCirculation tumor DNA in predicting recurrence and prognosis in operable colorectal cancer patients: a meta-analysis.
Selecting the appropriate patient for further treatment after surgery and adjuvant chemotherapy (ACT) for colorectal cancer (CRC) can improve the patient's prognosis. Circulating tumour DNA (ctDNA) has the potential to predict recurrence and prognosis after CRC surgery and ACT, but the results are still inconclusive. ⋯ ctDNA-positive patients were at a high risk of recurrence after CRC surgery and ACT and had a poorer prognosis. Hence, ctDNA-positive patients required close follow-up and further treatments.
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Eur. J. Clin. Invest. · Dec 2022
Ambulatory central BP and arterial stiffness in patients with and without intradialytic hypertension.
Increased arterial stiffness is suggested to be involved in the pathogenesis of intradialytic-hypertension (IDH). Ambulatory pulse-wave-velocity (PWV) is an independent predictor for all-cause-mortality in haemodialysis and its prognostic power is better than office PWV. This is the first study examining ambulatory central blood pressure (BP) and arterial stiffness parameters in patients with and without IDH. ⋯ IDH patients have significantly higher levels of ambulatory central BP and arterial stiffness parameters and a different course over the 48-h period compared with non-IDH patients. Increased arterial stiffness could be a prominent factor associated with the high burden of cardiovascular disease in this population.