European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2023
ReviewSmall interference (RNAi) technique: Exploring its clinical applications, benefits and limitations.
Small interference RNA (siRNA) has emerged as the most desired method for researchers and clinicians who wish to silence a specific gene of interest and has been extensively developed as a therapeutic agent. This review points to collecting all clinical trials on siRNA and understanding its benefits, pharmacokinetics and safety by reading articles published in the last 5 years. ⋯ The siRNA or RNAi method will be one of the most critical and influential techniques to fight against many different diseases. Although the RNAi approach has certain advantages, it also has limitations concerning clinical applications. Overcoming these limitations remains a daunting challenge.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisReparixin improves survival in critically ill and transplant patients: A meta-analysis.
Reparixin, an anti-inflammatory drug that inhibits interleukin 8 (IL-8) activity, might be life-saving for high-risk in-hospital patients without increasing the risk of infection according to a previous meta-analysis. With the increasing availability of randomised data the aim of the current study is to update previous findings by including any randomised control trials (RCTs) investigating the impact of reparixin on survival of critically ill or transplant patients. ⋯ The findings of this meta-analysis indicate that reparixin, an anti-inflammatory drug, improved survival in critically ill or transplant patients (including both COVID-19 and non-COVID-19 patients) without increasing the risk of infection.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisImpact of vitamin D supplementation on markers of bone turnover: Systematic review and meta-analysis of randomised controlled trials.
The effects of vitamin D administration on bone turnover markers (BTMs) in adults are controversial. Thus, we carried out a meta-analysis of available randomised controlled trials (RCTs) to examine the impact of vitamin D supplementation on BTMs. ⋯ Vitamin D administration decreases DPD, PINP and ALP levels, indicating a reduced bone turnover following the intervention. Other BTMs, for example, CTX or OC values, were not affected by vitamin D prescription. Vitamin D supplementation may exert a positive effect on some important BTMs.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisImpact of vitamin D supplementation on markers of bone turnover: Systematic review and meta-analysis of randomised controlled trials.
The effects of vitamin D administration on bone turnover markers (BTMs) in adults are controversial. Thus, we carried out a meta-analysis of available randomised controlled trials (RCTs) to examine the impact of vitamin D supplementation on BTMs. ⋯ Vitamin D administration decreases DPD, PINP and ALP levels, indicating a reduced bone turnover following the intervention. Other BTMs, for example, CTX or OC values, were not affected by vitamin D prescription. Vitamin D supplementation may exert a positive effect on some important BTMs.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisAssociation of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
This study aimed to systematically evaluate the role of circulating levels of choline and betaine in the risk of cardiovascular disease (CVD) and all-cause mortality by comprehensively reviewing observational studies. ⋯ Higher levels of circulating choline were associated with a higher risk of CVD and all-cause mortality.