European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2023
ReviewExternal stenting for saphenous vein grafts in coronary artery bypass grafting: A meta-analysis.
Autologous saphenous vein grafts (SVGs) are the most commonly used bypass conduits in coronary artery bypass grafting (CABG) with multivessel coronary artery disease. Although external support devices for SVGs have shown promising outcomes, the overall efficacy and safety remains controversial. We aimed to evaluate external stenting for SVGs in CABG versus non-stented SVGs. ⋯ External support devices for SVGs significantly reduced the intimal hyperplasia area and thickness, and improved the lumen uniformity, assessed with the Fitzgibbon I classification. Meanwhile, they did not increase the overall SVG failure rate.
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Eur. J. Clin. Invest. · Nov 2023
Review Meta AnalysisLong-term safety of macitentan in patients with pulmonary hypertension: A meta-analysis of randomised controlled trials.
Macitentan has demonstrated its effectiveness in patients with pulmonary hypertension (PH), but its safety, especially for long-term use, needs to be further explored. This systematic review and meta-analysis aimed to determine the safety of long-term use of macitentan in patients with PH. ⋯ The long-term use of macitentan is safe for patients with PH, although with a higher risk of anaemia, headache and bronchitis.
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Eur. J. Clin. Invest. · Nov 2023
Human blood metabolites and risk of severe COVID-19: A Mendelian randomization study.
Evidence supports the observational associations of human blood metabolites with the risk of severe COVID-19. However, little is known about the potential pathological mechanisms and the analysis of blood metabolites may offer a better understanding of the underlying biological processes. ⋯ This study suggested a causal relationship between 3-hydroxybutyrate and the severity of COVID-19, thus providing novel insights into biomarkers and pathways for COVID-19 prevention and clinical interventions.