European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2023
Review Meta AnalysisLong-term safety of macitentan in patients with pulmonary hypertension: A meta-analysis of randomised controlled trials.
Macitentan has demonstrated its effectiveness in patients with pulmonary hypertension (PH), but its safety, especially for long-term use, needs to be further explored. This systematic review and meta-analysis aimed to determine the safety of long-term use of macitentan in patients with PH. ⋯ The long-term use of macitentan is safe for patients with PH, although with a higher risk of anaemia, headache and bronchitis.