European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2023
Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study.
Evidence of a clear causal relationship between telomere length and aortic aneurysms is limited by the potential for confounding or reverse causation effects. In this study, we used a Mendelian randomisation (MR) approach to investigate this putative causal association. ⋯ Our results support a possible causal association between telomere length and aortic aneurysms, providing new insights into the involvement of telomere biology in this condition and offering a potential avenue for targeted therapeutic interventions.