European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2024
Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus.
Seasonal variation and sunlight exposure can impact serum vitamin D levels, potentially influencing lupus symptoms. We investigated seasonal vitamin D levels and their correlation with clinical manifestations and disease activity in systemic lupus erythematosus (SLE). ⋯ Sufficient vitamin D levels are important for achieving LLDAS in patients with SLE during winter and summer. Therefore, physicians should pay attention to the adequacy of vitamin D levels and consider recommending vitamin D supplementation for patients with vitamin D insufficiency.
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Eur. J. Clin. Invest. · Jan 2024
Meta AnalysisThe relationship between sex hormone-binding protein and non-alcoholic fatty liver disease using Mendelian randomisation.
The incidence of non-alcohol fatty liver disease (NAFLD) has been increasing annually with the improvement of living standards. Numerous epidemiological observations have linked sex hormone-binding protein (SHBG) levels to NAFLD. However, evidence of the causal role of SHBG in the development and progression of NAFLD is still absent. Therefore, a systematic assessment of the causal relationship is needed. ⋯ The genetic tendency to high levels of SHBG was causally correlated with a reduced risk of NAFLD, indicating that circulating high levels of SHBG was a protective factor for NAFLD.
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Eur. J. Clin. Invest. · Jan 2024
Artificial intelligence evaluation of coronary computed tomography angiography for coronary stenosis classification and diagnosis.
Ruling out obstructive coronary artery disease (CAD) using coronary computed tomography angiography (CCTA) is time-consuming and challenging. This study developed a deep learning (DL) model to assist in detecting obstructive CAD on CCTA to streamline workflows. ⋯ The developed AI model identified obstructive CAD, and the model results correlated well with QCA results. Incorporating the model into the reporting system of CCTA may improve workflows.
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Eur. J. Clin. Invest. · Jan 2024
Depression in nonalcoholic fatty liver disease and all-cause/cause-specific mortality.
Depression has been associated with nonalcoholic fatty liver disease (NAFLD). Data addressing the impact of depression on NAFLD-related mortality are evolving. We aim to study the association of depression in NAFLD and all-cause/cause-specific mortality in the United States. ⋯ Depression among individuals with NAFLD was associated with a higher risk for all-cause and cardiovascular mortality in the United States.