European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2024
Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease.
Lipoprotein (a) [Lp(a)] is associated with coronary artery disease (CAD). However, the role of healthy lifestyle against the risk of CAD with consideration of high Lp(a) levels remains unclear. ⋯ Healthy lifestyle was associated with a lower risk of CAD regardless of Lp(a) levels.
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Eur. J. Clin. Invest. · Jan 2024
Meta AnalysisThe relationship between sex hormone-binding protein and non-alcoholic fatty liver disease using Mendelian randomisation.
The incidence of non-alcohol fatty liver disease (NAFLD) has been increasing annually with the improvement of living standards. Numerous epidemiological observations have linked sex hormone-binding protein (SHBG) levels to NAFLD. However, evidence of the causal role of SHBG in the development and progression of NAFLD is still absent. Therefore, a systematic assessment of the causal relationship is needed. ⋯ The genetic tendency to high levels of SHBG was causally correlated with a reduced risk of NAFLD, indicating that circulating high levels of SHBG was a protective factor for NAFLD.
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Eur. J. Clin. Invest. · Jan 2024
Randomized Controlled TrialBlood flow effects of percutaneous peripheral nerve stimulation. A blinded, randomized clinical trial.
The vasculature function is mainly regulated by the autonomic nervous system. Importantly, the sensory-motor nervous system also innervates peripheral vessels and has the capacity to modulate vascular tone. Here we investigated the effects of electrical stimulation of a mixed nerve trunk on blood flow in deep arteries and muscle perfusion. Our hypothesis is that stimulation of a mixed nerve can modify blood flow. ⋯ Therefore, the arterial blood flow in the arm is mainly impervious to the electrical stimulation of the median nerve, composed by autonomic and sensory-motor axons, although it produces mild modifications in the forearm muscles perfusion.
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Eur. J. Clin. Invest. · Jan 2024
Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades.
To assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional and national levels. ⋯ The burden of thalassemias and accompanying HF, as well as their temporal trends, vary greatly across countries and regions. These findings can improve understanding of these conditions and guide policymakers in developing appropriate policies to address disparities between countries.