European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2024
Temporal trends of gender disparities in oral anticoagulant use in patients with atrial fibrillation.
To investigate sex-specific temporal trends in the initiation of oral anticoagulant (OAC) therapy among patients diagnosed with atrial fibrillation (AF) in Finland between 2007 and 2018. ⋯ This nationwide retrospective cohort study covering all patients with incident AF in Finland from 2007 to 2018 observed that although female sex was initially associated with a lower initiation of OAC therapy, the sex-related disparities resolved over the course of the study period.
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Eur. J. Clin. Invest. · Jan 2024
Randomized Controlled TrialBlood flow effects of percutaneous peripheral nerve stimulation. A blinded, randomized clinical trial.
The vasculature function is mainly regulated by the autonomic nervous system. Importantly, the sensory-motor nervous system also innervates peripheral vessels and has the capacity to modulate vascular tone. Here we investigated the effects of electrical stimulation of a mixed nerve trunk on blood flow in deep arteries and muscle perfusion. Our hypothesis is that stimulation of a mixed nerve can modify blood flow. ⋯ Therefore, the arterial blood flow in the arm is mainly impervious to the electrical stimulation of the median nerve, composed by autonomic and sensory-motor axons, although it produces mild modifications in the forearm muscles perfusion.
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Eur. J. Clin. Invest. · Jan 2024
Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades.
To assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional and national levels. ⋯ The burden of thalassemias and accompanying HF, as well as their temporal trends, vary greatly across countries and regions. These findings can improve understanding of these conditions and guide policymakers in developing appropriate policies to address disparities between countries.
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Eur. J. Clin. Invest. · Jan 2024
Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease.
Lipoprotein (a) [Lp(a)] is associated with coronary artery disease (CAD). However, the role of healthy lifestyle against the risk of CAD with consideration of high Lp(a) levels remains unclear. ⋯ Healthy lifestyle was associated with a lower risk of CAD regardless of Lp(a) levels.