European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2025
The use of the Crohn's disease exclusion diet (CDED) in adults with Crohn's disease: A randomized controlled trial.
The Crohn's disease exclusion diet (CDED) has been shown to induce remission in adult Crohn's disease (CD) patients. The aim of the study is to provide additional evidence-based validation. ⋯ The CDED was effective in inducing remission among patients with mild-to-moderate CD and appeared to be safe and well-accepted.
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Eur. J. Clin. Invest. · Jan 2025
ReviewImaging predictors of adverse prognosis in Fabry disease cardiomyopathy: A systematic review and meta-analysis.
Cardiac involvement represents the main cause of death in patients with Fabry disease (FD). Echocardiography and cardiovascular magnetic resonance (CMR) have an established diagnostic role, but their prognostic value remains unresolved. This systematic review and meta-analysis sought to assess the prognostic implications of imaging parameters in FD. ⋯ Several imaging parameters were significant predictors of adverse clinical outcomes in patients with FD. Late gadolinium enhancement showed the strongest association with adverse prognosis.
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Eur. J. Clin. Invest. · Jan 2025
Sexual dimorphism in exercise-induced response on steroid hormones to a 24-week supervised concurrent training intervention.
Steroid hormones are key mediators of adaptative responses to exercise, a stimulus that may concurrently affect their blood concentrations. However, the chronic endocrine adaptations and whether these potential changes are dependent on exercise intensity remain undetermined. Moreover, it is also unknown if the exercise-induced effects on steroid hormonal status are related to the participant' sex. ⋯ Our 24-week supervised concurrent training intervention showed no significant changes in steroid hormone levels. However, a significant decrement of T/C ratio was observed only in women, indicating a sexual dimorphism in the effect on T/C ratio.
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Eur. J. Clin. Invest. · Jan 2025
Meteorin-like protein plasma levels are associated with worse outcomes in de novo heart failure.
Meteorin-like protein (Metrnl) has been recently suggested as a new adipokine with protective cardiovascular effects. Its circulating levels in patients seem to be associated with heart failure (HF), although with contradictory results. Our aim was to ascertain whether this adipokine could estimate the prognosis of HF in de novo HF (DNHF) patients. ⋯ Patients with higher Metrnl levels have a worse prognosis in DNHF. Our results reinforce the association of Metrnl plasma levels with HF progression and outcomes.