European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2022
Multiparametric Analysis of Coronary Flow in Psoriasis Using a Coronary Flow Reserve Companion.
Coronary microvascular dysfunction (CMD) is usually evaluated measuring coronary flow velocity reserve (CFVR). A more comprehensive analysis of CFVR including additional consideration of the associated logical companion-CFVR, where hyperemic diastolic coronary flow velocity may act as surrogate, was applied in this study to elucidate the mechanism of CMD in psoriasis. ⋯ The reduced CFVR in psoriasis is driven by decreased companion-CFVR, combined with increased hyperemic MR. Adoption of the mandatory companion-CFVR enables a personalized characterization superior to that achieved by exclusive consideration of CFVR.
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Over the past few years, there has been an undiminished interest in lipoprotein(a) [Lp(a)] and oxidized phospholipids (OxPLs), mainly carried on this lipoprotein. Elevated Lp(a) has been established as an independent causal risk factor for cardiovascular disease. ⋯ The main questions that remain to be answered, however, is to what extent OxPLs contribute to the atherogenicity of Lp(a), what effect hypolipidaemic medications may have on their levels and the potential clinical benefit of their reduction. This narrative review aimed to summarize currently available data on OxPLs and cardiovascular risk, as well as the effect of established and emerging hypolipidaemic medications on Lp(a)-OxPLs.
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Eur. J. Clin. Invest. · Apr 2022
Multicenter StudyAn online nomogram of acute respiratory distress syndrome originating from pulmonary disease.
Acute respiratory distress syndrome (ARDS) is a highly heterogeneous disease accompanied by high mortality. Our goal was to investigate the risk factors for 28-day mortality and then establish a predictive online nomogram for ARDS originating from pulmonary disease (ARDSp). ⋯ For ARDSp patients, older males, lower C-reactive protein and albumin levels, and MODS were independent predictors of a poor 28-day prognosis. The online nomogram based on five independent factors could act as a predictive appliance in clinical practice.
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Eur. J. Clin. Invest. · Apr 2022
Class I HDAC Modulates Angiotensin II-induced Fibroblast Migration and Mitochondrial Overactivity.
Inhibition of histone deacetylases (HDACs) attenuates cardiac fibrosis. In this study, we evaluated whether the inhibition of class I HDACs can attenuate angiotensin II (ANG II)-induced fibrogenesis and mitochondrial malfunction through its effects on reactive oxygen species (ROS) and calcium dysregulation in human cardiac fibroblasts (CFs). ⋯ Modulating mitochondrial function by regulation of HDAC may be a novel strategy for controlling CF activity.
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Eur. J. Clin. Invest. · Apr 2022
Fibrinogen β chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism.
Prothrombotic fibrin clot properties, including increased clot density, are in part genetically determined. We investigated whether fibrinogen alpha-chain gene (FGA) c.991A>G (rs6050), fibrinogen beta chain gene (FGB) -455G>A (rs1800790) and factor XIII gene (F13) c.103G>T (rs5985) polymorphisms affect plasma fibrin clot properties in patients with acute pulmonary embolism (PE). ⋯ Our study showed that FGB rs1800790 and F13 rs5985 polymorphisms contribute to the prothrombotic fibrin clot phenotype and these effects are strong enough to be observed in the acute phase of PE.