European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2022
Observational StudyAn observational study of the Covid-19 situation following the first pan-European mass sports event.
All events in Europe, including EURO2020 football championship, were postponed due to Covid-19 in 2020. Instead, Euro2020 took place in 2021, as mitigation measures were relaxed, cross-country mobility increased and the Delta variant was spreading across Europe. This study explored the possibility of an increased Covid-19 spread across Europe following EURO2020 matches. ⋯ The EURO2020 was an anticipated mass sports event, and it was the first-time spectators were allowed to enter stadiums in Europe. Stadiums instituted several mitigations to safeguard the spectators although reports of transmission were still present. The major challenges were the gatherings outside the stadiums that might have contributed to these observations. Targeted restrictions might be required during mass sport events especially in the presence of highly transmissible variant(s) and low vaccination rates among the young generation.
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Eur. J. Clin. Invest. · Apr 2022
Delayed perihematomal hypoperfusion is associated with poor outcome in intracerebral haemorrhage.
The aim of this study was to characterize the temporal evolution and prognostic significance of perihematomal perfusion in acute intracerebral haemorrhage (ICH). ⋯ Perihaemorrhagic hypoperfusion becomes more severe in the days following acute ICH and is independently associated with poorer outcome. Understanding the underlying biological mechanisms responsible for delayed decrease in perihematomal perfusion is a necessary step towards outcome improvement in patients with ICH.
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Eur. J. Clin. Invest. · Apr 2022
Gamma-glutamyl transferase and cardiovascular events in patients with congenital heart disease.
Serum gamma-glutamyl transferase activity (GGT) seems to predict cardiovascular events in different populations. However, no data exist on patients with congenital heart disease (CHD). ⋯ Patients with CHD showed significant higher GGT levels than patients in the control group having those with higher GGT concentrations (>60 U/L) the worst survival.
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Eur. J. Clin. Invest. · Apr 2022
Evaluation of crossed cerebellar diaschisis after cerebral infarction in MCAO rats based on DKI.
To observe the expression of N-methyl-D-aspartate (NMDA), apoptosis and the effect on neurological function recovery in rat model with middle cerebral artery occlusion (MCAO). Diffusion kurtosis imaging (DKI) was used to evaluate crossed cerebellar diaschisis (CCD) and to provide experimental and theoretical basis for the clinical treatment. ⋯ It is found that NMDA and DKI of CCD have the same changing trend, which indicates that the intervention of NMDA receptor apoptosis may become a new target for the treatment of cerebral infarction, and MRI parameters can predict the occurrence and development of CCD.
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Eur. J. Clin. Invest. · Apr 2022
Elevated uric acid is related to the no-/slow-reflow phenomenon in STEMI undergoing primary PCI.
No-/slow-reflow phenomenon (NRP) is a severe complication in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). This study aimed to explore the relationship between elevated serum uric acid (SUA) and NRP in patients with STEMI undergoing pPCI, focusing on inflammation and angiographic findings. ⋯ Elevated SUA is associated with severe inflammation and has higher incidence of TIMI-NRP in patients with STEMI undergoing pPCI, especially in those with delayed perfusion or diabetes mellitus.