European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2022
Meta AnalysisVariants of Candidate Genes Associated with the Risk of Obstructive Sleep Apnea.
The researches on the associations between different candidate genes and obstructive sleep apnea (OSA) are inconsistent. Here, we performed a comprehensive qualitative and quantitative analysis to estimate the contribution of variants from candidate genes to the risk of OSA. ⋯ Eleven variants from the candidate genes are associated with the risk of OSA, which also show ethnicity differences in East Asian and European subgroups.
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Eur. J. Clin. Invest. · Jan 2022
Increased Estimated Fat-free and Fat Mass Associated with Improved Clinical Outcome in Heart Failure.
Increased weight measured by body mass index is associated with better clinical outcomes in heart failure (HF). The effect of specific components of body mass on outcome is limited. We evaluated the impact of fat-free mass and fat mass on mortality and cardiovascular hospitalization in a large real-world cohort of patients with chronic HF. ⋯ Body mass including fat-free mass and fat mass was associated with improved survival in patients with HF.
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Eur. J. Clin. Invest. · Jan 2022
ReviewThe skin microbiome of infected pressure ulcers: A review and implications for health professionals.
Pressure ulcers (PUs) are injuries resulting from ischaemia caused by prolonged compression or shear forces on the skin, adjacent tissues and bones. Advanced stages of PUs are associated with infectious complications and constitute a major clinical challenge, with high social and economic impacts in health care. ⋯ Development of PUs and consequent infection depends on several direct and indirect risk factors, including cutaneous/PU microbiome, microclimate and behavioural factors. Infected PUs are polymicrobial and characterized by biofilm-associated infection, phenotypic hypervariability of species and inherent resistance to antimicrobials. The different stages and anatomical locations also play an important role in their colonization. The prevention and monitoring of PUs remain crucial for avoiding the emergence of systemic infections and reducing health care-associated costs, improve the quality of life of patients and reduce the mortality-associated infected PUs.
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Eur. J. Clin. Invest. · Jan 2022
Isoprostane-8 and GDF-15 as novel markers of post-PE syndrome: relation with prothrombotic factors.
Post-pulmonary embolism (PE) syndrome occurs in up to 50% of PE patients. The pathophysiology of this syndrome is obscure. ⋯ Enhanced oxidative stress and prothrombotic fibrin clot properties could be involved in the pathogenesis of the post-PE syndrome. Elevated growth differentiation factor 15 assessed at 3 months might be a new biomarker of this syndrome.