European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2021
Review Meta AnalysisGlucocorticoids for Acute Respiratory Distress Syndrome: a systematic review with meta-analysis and trial sequential analysis.
Glucocorticoids are some of the most commonly used drugs for patients with acute respiratory distress syndrome (ARDS). However, the curative effect and side effects of glucocorticoids in treating patients with ARDS remain controversial. ⋯ Longer- and lower-dose glucocorticoid treatment may improve the prognosis of ARDS patients, but RCTs with higher quality and larger sample sizes are needed to further clarify the clinical effects of glucocorticoids on ARDS.
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Eur. J. Clin. Invest. · Jun 2021
Review Meta AnalysisCovid-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis.
COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). ⋯ Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.
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Eur. J. Clin. Invest. · Jun 2021
ReviewProcedure-related bleeding risk in patients with cirrhosis and severe thrombocytopenia.
Gaps of knowledge still exist about the potential association between severe thrombocytopenia and increased risk of procedure-associated bleeding in patients with liver disease. ⋯ Currently available literature cannot support definitive conclusions about the appropriate target platelet counts to improve the risk of bleeding in cirrhotic patients who underwent invasive procedures; moreover, it showed enormous variability in the use of prophylactic platelet transfusions.
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Eur. J. Clin. Invest. · Jun 2021
Comparative StudyNon-vitamin K antagonist oral anticoagulants versus warfarin in AF patients ≥ 85 years.
Atrial fibrillation (AF) prevalence and its risk of stroke rise with ageing. We aimed to investigate the outcomes of NOAC and warfarin in AF patients aged ≥ 85 years. ⋯ For the efficacy, NOACs were associated with a comparable or lower risk of ischaemic stroke compared to warfarin. For adverse events, NOACs were associated with a lower risk of all-cause mortality and composite adverse events. In the elderly AF population, NOACs could be a more favourable choice for stroke prevention.
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Eur. J. Clin. Invest. · Jun 2021
Effects of age and comorbidities on serum levels of inflammatory markers in community-acquired pneumonia.
Studies have suggested that an inappropriate inflammatory response is a major cause of treatment failure and mortality in patients with community-acquired pneumonia (CAP). We aimed to determine the effect of age and comorbidities on serum inflammatory markers in CAP. ⋯ The circulating inflammatory markers to CAP have profiles that differ with age and underlying comorbidities. Multimorbidity in the elderly is also associated with lower serum levels of some inflammatory markers. Our findings suggest that inflammatory markers in CAP should be interpreted after considering age and comorbid conditions.