European journal of clinical investigation
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Eur. J. Clin. Invest.
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Eur. J. Clin. Invest. · May 2021
Review Meta AnalysisThe association between serum homocysteine and depression: a systematic review and meta-analysis of observational studies.
Hyperhomocysteinaemia is known to interfere with neurological functions; however, there is a controversy regarding the relationship between homocysteine and depression. ⋯ Homocysteinemia level is higher in individuals with depression. However, the depression diagnostic tool used is instrumental in influencing their association, and thus, future studies should focus on the tools for depression assessment.