European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2020
Meta AnalysisCarotid intima-media thickness predicts carotid plaque development: Meta-analysis of seven studies involving 9341 participants.
Carotid intima-media thickness and carotid plaque are well-established imaging markers used to capture different stages of the atherosclerotic disease process. We aimed to quantify to which extent carotid intima-media thickness predicts incidence of first-ever carotid plaque. ⋯ In general population studies, elevated baseline carotid intima-media thickness is associated with incidence of carotid plaque in individuals free of carotid plaque at baseline.
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Eur. J. Clin. Invest. · Apr 2020
Review Meta AnalysisGenetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis.
Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. ⋯ Out of 68 published associations of miRNA polymorphisms with cancer, sixteen have shown noteworthiness in our re-assessing meta-analysis. Our findings summarize the results of meta-analyses on the association of cancer with SNPs and underline the importance of interpreting results with caution.