European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2019
Pulse pressure and prognosis in patients with heart failure with reduced ejection fraction.
A high pulse pressure (PP) is associated with adverse cardiovascular (CV) outcomes; however, this relationship may be reversed in patients with heart failure with reduced ejection fraction (HFREF). ⋯ In patients with advanced HFREF, a low PP (<40 mm Hg) portends a worse prognosis, whereas a high PP (>50 mm Hg) predicts a relatively favourable prognosis.
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To analyse whether the weight ratio of potassium-to-magnesium intake is associated with incident high blood pressure, in otherwise healthy individuals. ⋯ Our results suggest that, in healthy individuals with magnesium and potassium intake below recommended dietary allowance, the high potassium-to-magnesium ratio is inversely associated with incident high blood pressure.
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Eur. J. Clin. Invest. · May 2019
Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis.
Cholangiocarcinoma (CCA) complicates primary sclerosing cholangitis (PSC) in 10%-20% of cases, but current tools for prediction of a CCA diagnosis are inadequate. Recently, we demonstrated the utility of the enhanced liver fibrosis (ELF) test to stratify prognosis in PSC. We observed that patients with PSC + CCA had significantly higher ELF score than those with PSC alone. In this study, we aimed to investigate further this association in a larger cohort of PSC patients with CCA compared with patients with PSC or CCA alone. ⋯ Enhanced liver fibrosis score was elevated in patients with CCA irrespective of the presence of PSC, and independently of liver disease stage. Our results indicate that the association between high ELF score and CCA may be related to the tumour's desmoplastic nature, independent of background liver fibrosis, suggesting that ELF score could be used to risk stratify for CCA in PSC.