European journal of clinical investigation
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Eur. J. Clin. Invest. · May 2019
Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians.
The importance of ectopic fat deposition and physical fitness in the pathogenesis of insulin resistance and beta cell dysfunction in subjects from the nonobese Asians is not known. ⋯ Increased ectopic fat deposition is associated with reduced insulin sensitivity and increased insulin secretion in healthy nonobese Asians. Poor cardiorespiratory fitness, likely due to inadequate participation in vigorous exercise, is strongly related to suboptimal metabolic function. Interventions to encourage engagement in physical activity may thus be important for improving metabolic health in nonobese Asians.
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Eur. J. Clin. Invest. · Apr 2019
Review Meta AnalysisPrognostic value of hyperuricemia in patients with acute coronary syndrome: A meta-analysis.
The prognostic significance of elevated circulating uric acid level in patients with acute coronary syndrome (ACS) is conflicting. This meta-analysis aimed to assess the prognostic value of hyperuricemia in patients with ACS. ⋯ This meta-analysis suggests that hyperuricemia independently predicts MACEs and death in ACS patients. Determination of uric acid level has potential to improve risk stratification of adverse outcomes in ACS patients.
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Eur. J. Clin. Invest. · Apr 2019
Observational StudyCausal association between body mass index and risk of rheumatoid arthritis: A Mendelian randomization study.
This study aimed to examine whether body mass index (BMI) is causally associated with rheumatoid arthritis (RA). ⋯ The results of MR analysis support that BMI may be causally associated with an increased risk of RA.
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Eur. J. Clin. Invest. · Mar 2019
Associations of secreted phosphoprotein 1 and B lymphocyte kinase gene polymorphisms with autoimmune thyroid disease.
Dysregulation of the type 1 interferon (IFN)-related signalling pathway predisposes one to autoimmune diseases. Possible associations of single-nucleotide polymorphisms (SNPs) of secreted phosphoprotein 1 (SPP1) and B lymphocyte kinase (BLK) of the type 1 IFN-related signalling pathway with autoimmune thyroid disease (AITD) in an ethnic Chinese (ie Taiwanese) population were tested. ⋯ Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population. Our results suggest the BLK may participate in the pathogenesis of GD, HT and AITD.