European journal of clinical investigation
-
Eur. J. Clin. Invest. · Dec 1999
L-selectin in trauma patients: a marker for organ dysfunction and outcome?
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are important factors affecting morbidity and mortality after trauma. Adhesion molecules, e.g. L-selectin (CD62 L), play crucial roles in both conditions. ⋯ In multiple trauma patients, severe organ dysfunction is associated with altered CD62 L expression on leukocytes and circulating sCD62 L plasma concentrations. However, the obvious complexity of the pattern currently restricts use of CD62 L quantitation for clinical purposes.
-
Eur. J. Clin. Invest. · Dec 1999
The p22 phox polymorphism C242T is not associated with CHD risk in Asian Indians and Chinese.
Oxygen free radicals such as superoxide anion have been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD). The nonglycosylated 22 kDa alpha-subunit of the NADH/NADPH oxidase (p22 phox) of the vasculature acts as the final electron transporter in the generation of superoxide anion. Recently, a common polymorphism (C242T) at codon 72 in the p22 phox gene has been reported to be associated with CHD risk. ⋯ The p22 phox codon 72 polymorphism is not associated with the risk of CHD in the present samples of Asian Indians and Chinese.
-
Eur. J. Clin. Invest. · Sep 1999
NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population.
Oxidative stress induced by the superoxide anion (.O2-) has been implicated in atherogenesis. The NADH/NADPH oxidase system is involved in.O2- production and p22 phox is an essential component of that system. ⋯ The p22 phox C242T polymorphism is not associated with the occurrence or severity of CAD or with a history of MI in Australian Caucasian patients aged
-
Eur. J. Clin. Invest. · Sep 1999
Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort.
The recently described A-->G (-3826) point mutation within the distal region of the UCP-1 promoter is possibly involved in the development of obesity, diabetes and related metabolic disorders. It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes. ⋯ We determined the genotype and allelic frequency of the UCP-1 promoter polymorphism in the largest known population-based study. The results from genotyping demonstrate clearly that this polymorphism does not play a major role in the pathogenesis obesity and diabetes. A yet unknown adipocyte derived and differentiation-dependent regulated transcription factor is able to bind to the distal UCP-1 promoter surrounding -3826 bp. This binding is not affected by presence of the mutation.
-
Eur. J. Clin. Invest. · Aug 1999
Plasma acylation stimulating protein, adipsin and lipids in non-obese and obese populations.
Acylation stimulating protein (ASP) is a potent stimulator of TG synthesis in human adipocytes. ⋯ The present data suggest involvement of the ASP/adipsin pathway in the pathogenesis of obesity.