European journal of clinical investigation
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Eur. J. Clin. Invest. · Oct 2023
Metabolomics reveals serum metabolic signatures in H-type hypertension based on mass spectrometry multi-platform.
H-type hypertension (HHT) is a disease combined with hyperhomocysteinaemia and hypertension (HT). This study aims to find specific metabolic changes and reveal the pathophysiological mechanism of HHT, which provide the theoretical basis for the early prevention and treatment of HHT. ⋯ Metabolomics analysis by mass spectrometry multi-platform revealed the differences of metabolic profiles between HHT and HT subjects. This work laid the groundwork for understanding the aetiology of HHT, and these findings may provide the useful information for explaining the HHT metabolic alterations and try to prevent HHT.
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Eur. J. Clin. Invest. · Oct 2023
Excessive salt intake reduces bone density in the general female population.
Osteoporosis is a multifactorial disorder in which nutrition is associated with its onset and progression. Excessive salt intake is closely associated with the onset and progression of various diseases, such as osteoporosis and hypertension. We investigated the effects of dietary salt intake on bone density in the general female population. ⋯ We confirmed that excessive salt intake reduces bone density independently of age and lifestyle-related diseases in the general female population. Since dietary salt intake is a modifiable factor, osteoporosis can be prevented by dietary intervention, including salt reduction.
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Eur. J. Clin. Invest. · Oct 2023
Hypothesis-free discovery of novel cancer predictors using machine learning.
Cancer is a leading cause of morbidity and mortality worldwide, and better understanding of the risk factors could enhance prevention. ⋯ This hypothesis-free analysis suggests personal characteristics, metabolic biomarkers, physical measures and smoking as important predictors of cancer risk, with further studies needed to confirm causality and clinical relevance.
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Eur. J. Clin. Invest. · Oct 2023
Association between spirometry pattern, left ventricular diastolic function, and mortality.
Spirometric abnormalities have been related to incident heart failure in general population, who generally have preserved left ventricular ejection fraction (LVEF). We aimed to investigate the association between spirometric indices, cardiac functions and clinical outcomes. ⋯ The restrictive spirometry pattern or the declined FVC was associated with left ventricular diastolic dysfunction, which aggravated the long-term mortality in the ambulatory dyspnoeic subjects.
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Eur. J. Clin. Invest. · Oct 2023
Review Meta AnalysisAssociation of choline and betaine with the risk of cardiovascular disease and all-cause mortality: Meta-analysis.
This study aimed to systematically evaluate the role of circulating levels of choline and betaine in the risk of cardiovascular disease (CVD) and all-cause mortality by comprehensively reviewing observational studies. ⋯ Higher levels of circulating choline were associated with a higher risk of CVD and all-cause mortality.