European journal of clinical investigation
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Eur. J. Clin. Invest. · Aug 2023
Review Meta AnalysisMeta-analysis of Factors Associated with Antidiabetic Drug Prescribing for Type 2 Diabetes Mellitus.
There is a lack of consensus on prescribing alternatives to initial metformin therapy and intensification therapy for type 2 diabetes mellitus (T2DM) management. This review aimed to identify/quantify factors associated with prescribing of specific antidiabetic drug classes for T2DM. ⋯ Several factors were identified as potential determinants of antidiabetic drug prescribing. The magnitude and significance of each factor differed by antidiabetic class. Patient's age and baseline BMI had the most significant association with the choice of four out of the seven studied antidiabetic drugs followed by the baseline HbA1c and kidney-related problems which had an impact on three studied antidiabetic drugs, whereas sex had the least impact on prescribing decision as it was associated with GLP1-RA and thiazolidinedione only.
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Eur. J. Clin. Invest. · Aug 2023
Letter ReviewThe definition of long COVID used in interventional studies.
There has been little consensus for a specific definition of long COVID, though several organizations have created varying ones. We sought to examine the definition of long COVID used in ongoing clinical trials. ⋯ Standardized definitions of long COVID should be applied in studies assessing this condition to unify and harmonize research on this topic.
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Eur. J. Clin. Invest. · Aug 2023
Changes in biomarkers of endothelial function, oxidative stress, inflammation and lipids after smoking cessation: a cohort study.
Tobacco use is known to be involved in the development of cardiovascular diseases, which leads to premature mortality. Endothelial dysfunction, the first step in this process, was shown induced by smoking. It is reported that quitting smoking could reduce the risk of diseases, but the implied mechanisms are still unclear. This study aimed to evaluate the biological markers of endothelial function in smokers when actively smoking and after cessation. ⋯ These observations suggest that some adverse effects of smoking on endothelial function could be reversible on quitting smoking. It could encourage smokers to enter a cessation program to reduce the risk for cardiovascular diseases development.