European journal of clinical investigation
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Eur. J. Clin. Invest. · Aug 2023
Association between sleep traits and primary liver cancer: A Mendelian randomization analysis.
Primary liver cancer (PLC) is the sixth most frequently occurring cancer, representing one of the top 5 leading causes of cancer-related mortality worldwide. Recently, researchers have focused more on the impact of living habits on the incidence and development of tumours. This study reports a relationship between sleep traits and PLC. ⋯ Overall, our study indicates that insomnia and nap during the day may be risk factors of PLC and adequate night sleep might keep us away from PLC.
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Eur. J. Clin. Invest. · Aug 2023
Rebooting Disruptive Science: Exploring the challenges and potential solutions.
There has been a decline in the number of disruptive scientific discoveries and breakthroughs. Here, reasons for the decline of disruptive science are explored including declining funding for basic research, increasing risk-aversion among scientists, pressure to publish quickly and increasing administrative workload. Solutions are proposed to reverse the trend and encourage disruptive research especially for young scientists.
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Eur. J. Clin. Invest. · Aug 2023
Modified Rapid Emergency Medicine Score-Lactate (mREMS-L) performance to screen non-anticipated 30-day related-mortality in Emergency Department.
The aim of this study was to compare the ability to predict 30-day in-hospital mortality of lactate versus the modified Rapid Emergency Medicine Score (mREMS) versus the arithmetic sum of the mREMS plus the numerical value of lactate (mREMS-L). ⋯ The new score generated, mREMS-L, obtained better statistical results than its components (mREMS and lactate) separately.
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Eur. J. Clin. Invest. · Aug 2023
Dysfunctional antioxidant capacity of high-density lipoprotein in rheumatoid arthritis.
High-density lipoprotein (HDL) presents atheroprotective functions not readily reflected by plasma HDL-cholesterol levels. The aim of this study was to investigate HDL antioxidant function in patients with rheumatoid arthritis (RA). ⋯ Rheumatoid arthritis patients present reduced HDL antioxidant capacity and a lower resistance of LDL particles to oxidation, mainly related to the degree of inflammation.
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Eur. J. Clin. Invest. · Aug 2023
Effects of MBOAT7 polymorphism and steatosis on liver function assessed by methacetin breath-test.
MBOAT7 rs641738 variant is a risk factor for nonalcoholic fatty liver disease (NAFLD) and liver fibrosis, but the relationship between this polymorphism and early liver dysfunction remains uncertain. ⋯ The homozygous MBOAT7 rs641738 polymorphism per se is associated with a reduced extraction efficiency of (13 C)-methacetin from the portal flow pointing to subclinical liver dysfunction independently from liver fibrosis. Liver steatosis worsens (13 C)-methacetin extraction efficiency. We urge to better explore the mechanisms of interaction between external factors and multiple gene polymorphisms (including MBOAT7), paving the road to primary prevention and novel therapeutic strategies.